Cortactin gene
WebDescription: Homo sapiens cortactin (CTTN), transcript variant 2, mRNA. (from RefSeq NM_138565) RefSeq Summary (NM_138565): This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. WebCttn Gene Detail Summary Symbol Cttn Name cortactin Synonyms 1110020L01Rik, Ems1 Feature Type protein coding gene IDs MGI:99695 NCBI Gene: 13043 Alliance gene page Transcription Start Sites 2 TSS Location & Maps more Sequence Map Chr7:143989470-144024746 bp, - strand From Ensembl annotation of GRCm39 Genetic Map …
Cortactin gene
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WebWithin the amplified region several candidate oncogenes have been mapped, including cyclin D1, TAOS1 and cortactin. Yet, it is unknown which gene(s) is/are responsible for the selective pressure enabling amplicon formation. This is probably due to the use of low-resolution detection methods. Furthermore, the size and structure of the amplified ... WebJul 9, 2024 · Cortactin was upregulated in lung cancer tissues and could be a marker of poorer prognosis in human NSCLC. a Expression profiles of CTTN in primary lung cancer and matched normal tissues were reported as 2 -∆Ct values. b and c Kaplan-Meier curves for progression-free survival (PFS) and overall survival (OS) according to expression …
WebFeb 12, 2024 · Cortactin has been shown to control the integrity of the endothelial barrier and to support neutrophil transendothelial migration in vitroand in vivoin the skin. Here … WebGene silencing by shRNA to PAR2, RhoA, and cortactin attenuated this gene upregulation and migration induced by FVIIa/TF. Utilizing immunocellular localization, we demonstrate that during FVIIa/TF and PAR2 activation, cortactin molecules translocate from the cytoplasm to the cell periphery and assist in lamellipodia formation of pCMVECs.
WebCTTN provided by HGNC Official Full Name cortactin provided by HGNC Primary source HGNC:HGNC:3338 AllianceGenome:HGNC:3338 Gene type protein coding RefSeq … WebMar 21, 2024 · CTTN (Cortactin) is a Protein Coding gene. Diseases associated with CTTN include Squamous Cell Carcinoma and Wiskott-Aldrich Syndrome. Among its …
http://genome.cse.ucsc.edu/cgi-bin/hgGene?hgsid=1604955425_w5djzH9iDcSubb1ij3WuBC4fAfz7&hgg_section_go_close=1
WebFeb 14, 2005 · Cortactin is an F-actin-binding protein involved in cytoskeletal rearrangements and cell migration by promoting actin-related protein (Arp)2/3 mediated … hvac contractors in havertown paWebMar 29, 2024 · Background The nucleation-promoting factor cortactin is expressed and promotes tumor progression and metastasis in various cancers. However, little is known about the biological role of cortactin in the progression of pancreatic ductal adenocarcinoma (PDAC). Methods Cortactin and phosphorylated cortactin (Y421) … mary veal yogaWebCortactin is an actin filament-binding protein localizing at cortical regions of cells and a prominent substrate for Src family protein-tyrosine kinases in response to multiple extracellular stimuli. Human cortactin has been identified as a protein product of a putative oncogene, EMS1. ... We found that the DCortactin gene is situated on the ... hvac contractors in kearny mesaWebCortactin is a multidomain protein that functions as a key regulator of the actin cytoskeleton. It has roles in many actin-based cellular processes, including cell migration and invasion, tumor cell metastasis, and endocytosis (summary by Tegtmeyer et al., 2011 ). … mary veatchWebCTTN and CCND1 chromogenic in situ hybridisation (CISH) probes and a validated monoclonal antibody against CTTN were applied to a tissue microarray of a cohort of … mary vaughn steve harvey ex wifeWebCortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM … hvac contractors in indianapolisWebJul 1, 1998 · Cortactin, a p80/85 protein first identified as a src kinase substrate, is thought to be involved in the signaling pathway of mitogenic receptors and adhesion molecules … mary vedvik obituary wisconsin death notices