Klf5 gastric cancer

Author: ktsk

August undefined, 2024

WebSep 7, 2024 · KLF5 is a member of the Kruppel-like factor, subfamily of zinc finger proteins that are involved in cancers. KLF5 functions as a transcription factor and regulates the diverse protein-coding genes (PCGs) in colorectal cancer (CRC). However, the long non-coding RNAs (lncRNAs) regulated by KLF5 in CRC are currently unknown. Methods WebKrüppel-like factors (KLFs), such as KLF4, KLF2, KLF5 and KLF15, have been extensively investigated in multi-cancers. However, KLF16, a member of KLFs, hasn't been well identified in cancer, especially in gastric cancer (GC). Here, we investigated the roles of KLF16 in GC. In present study, we found that KLF16 expression levels were ...

KLF5 KLF transcription factor 5 - NIH Genetic Testing Registry …

WebThe regulation of KLF5 on expression levels of p21 and CDK4 in GC cells was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) and Western blot. Results: … WebApr 24, 2024 · The function of KLF5 in cell proliferation was studied in gastric cancer cell lines and organoids. We found that KLF5 amplification mainly occurred in the chromosome instable tumors (CIN) and was significantly associated with TP53 mutation. In addition, higher KLF5 expression correlated with more locally invasive gastric cancer and higher T … massano - the feeling zippy

FDA Accepts Application Seeking Approval of Keytruda-Chemo …

WebMar 17, 2024 · Acetylation of KLF5 promotes cancer cell-induced bone metastatic lesions while maintaining the mesenchymal phenotype of cancer cells. a, b Bone metastatic growth of PCa cells (DU 145, ... Xie L, et al. CXCR4, a potential predictive marker for docetaxel sensitivity in gastric cancer. Anticancer Res. 2010; 30:2209–2216. ... WebAbstract. Intestinal metaplasia (IM) is the inevitable precancerous stage to develop intestinal-type gastric cancer (GC). Deoxycholic acid (DCA) is the main bile acid (BA) component of duodenogastric reflux and has shown an increased concentration during the transition from chronic gastritis to IM associated with continued STAT3 activation. WebApr 13, 2024 · 5. Diet. Pickled, salted, and smoked foods can increase the risk of stomach cancer. Fresh fruits and vegetables can lower the risks. 6. Helicobacter Pylori Infection. This bacteria causes ... massanutten lift tickets promo code

KLF5 Is Activated by Gene Amplification in Gastric Cancer and Is ...

KLF5 promotes proliferation in gastric cancer via regulating p21 …

WebFeb 15, 2024 · KLF5 and MYC modulated LINC00346 contributes to gastric cancer progression through acting as a competing endogeous RNA and indicates poor outcome Cell Death & Differentiation Article 15... WebOBJECTIVE: This study aims to investigate the expression characteristics of Krüppel-like factor 5 (KLF5) in gastric cancer (GC) and its potential correlation to pathological indexes … hydraulic trash pumpWebKLF5 is involved in the initiation and development of diverse cancers in a context-dependent manner. KLF5 promotes several cancers, such as breast cancer, CRC, bladder cancer, and … massanutten 15 day weather forecast

"WebA suspicious renal mass discovered at the same time as a documented cancer is usually a malignant lesion and may justify combined radical surgical treatment. The authors report the natural history of a suspicious renal mass in a patient with primary gastric tumour corresponding to a MPT syndrome. They recall and discuss the epidemiology ... " - Klf5 gastric cancer

Klf5 gastric cancer

Tissue expression of KLF5 - Summary - The Human Protein Atlas

WebProtect Your Health: 5 Ways to Prevent Stomach CancerProtect your health and learn about the 5 ways to prevent stomach cancer. In this informative video, we'... WebOct 26, 2024 · We investigated the expression of KLF5 and miR-145-5p messenger RNA (mRNA) in gastric cancer and then analyzed its role in the biological behavior of gastric …

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WebApr 30, 2024 · For instance, KLF5-activated lncRNA NEAT1 accelerated gastric cancer progression via serving as a scaffold for BRG1 to down-regulate GADD45A expression . KLF5-regulated lncRNA RP1 contributed to cell proliferation and metastasis in breast cancer through suppressing p27kip1 translation . Overall, the abnormal increase of BBOX1-AS1 … WebApr 13, 2024 · Case: The population in the case group signed an informed consent form, aged between 18 and 75 years. All subjects underwent endoscopic examination and were confirmed by pathological diagnosis as gastric cancer, including high-grade intraepithelial neoplasia, early gastric cancer, and advanced gastric cancer.

WebSep 10, 2024 · Ma and colleagues demonstrated the functions and mechanism of lncRNA NEAT1 in gastric cancer tumorigenesis. NEAT1, which was induced by KLF5, promoted cell proliferation and inhibited apoptosis. Mechanistically, NEAT1 bound BRG1 directly, modulating histone methylation modification to regulate GADD45A-dependent G2/M cell … WebJul 11, 2007 · Overall KLF5 was found to be expressed in 45.7% (113/247) of tumor tissues. Moreover, its expression rate was significantly high in early-staged gastric cancer (63.2 vs. 38.0%, p < 0.001), in gastric cancer without lymph node metastasis (54.0 vs. 40.1%, p = 0.04), and in tumors <5 cm in size (53.0 vs. 38.1%, p = 0.02).

WebDec 15, 2024 · The analysis reveals that the KLF5 DNA recognition sequence is one of the top three motifs enriched in chromatin accessible regions found in squamous, colorectal, … WebApr 13, 2024 · 5. Diet. Pickled, salted, and smoked foods can increase the risk of stomach cancer. Fresh fruits and vegetables can lower the risks. 6. Helicobacter Pylori Infection. …

WebSep 24, 2013 · KLF5 is downregulated in some types of breast cancer but upregulated in others, and has opposite effects on proliferation in different breast cancer subtypes 90, 91; these seemingly...

WebApr 24, 2024 · The function of KLF5 in cell proliferation was studied in gastric cancer cell lines and organoids. We found that KLF5 amplification mainly occurred in the chromosome instable tumors (CIN) and was ... hydraulic tree felling jackWebKLF5. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. hydraulic trash can tipperWebResults 22 recurrent focal alterations (13 amplifications and nine deletions) were identified. These included both known targets (FGFR2, ERBB2) and also novel genes in gastric cancer (KLF5, GATA6).Receptor tyrosine kinase (RTK)/RAS alterations were found to be frequent in gastric cancer. This study also demonstrates, for the first time, that these alterations … massanutten country corner luray vaWebKLF5 and GATA factors are independently amplified but coexpressed in gastric cancer (GC). (A) Focal genomic amplifications of KLF5, GATA4 and GATA6 in GC. Chromosomal … massanutten beer and wine festivalWebStomach cancer is a slow-growing cancer that begins in the stomach lining and, if not detected early, can spread to the outer layers of the stomach. Afterwards the stomach cancer can invade through the stomach wall and enter the blood stream or lymph nodes. This allows stomach cancer cells to spread into nearby organs such as the pancreas and ... hydraulic tree cutting equipmentWebApr 4, 2024 · KLF5 promotes proliferation in gastric cancer via regulating p21 and CDK4. Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone … massanutten mountain villas official website massanutten coupons and discounts